Exosomes Released from Tumor-Associated Macrophages Transfer miRNAs That Induce a Treg/Th17 Cell Imbalance in Epithelial Ovarian Cancer
The immune microenvironment is crucial for epithelial ovarian cancer (EOC) progression and consists of tumor-associated macrophages (TAM) and T lymphocytes, such as regulatory T cells (Treg) and T helper 17 (Th17) cells. In this study, the Treg/Th17 ratio was significantly higher in EOC and in metas...
Saved in:
| Published in | Cancer immunology research Vol. 6; no. 12; p. 1578 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.12.2018
|
| Online Access | Get more information |
| ISSN | 2326-6074 |
| DOI | 10.1158/2326-6066.CIR-17-0479 |
Cover
Loading…
| Abstract | The immune microenvironment is crucial for epithelial ovarian cancer (EOC) progression and consists of tumor-associated macrophages (TAM) and T lymphocytes, such as regulatory T cells (Treg) and T helper 17 (Th17) cells. In this study, the Treg/Th17 ratio was significantly higher in EOC
and in metastatic peritoneal tissues than in benign ovarian tumors and benign peritoneum. The Treg/Th17 ratio was associated with histologic grade and was an independent prognostic factor for overall survival of EOC patients. On the basis of microarray analysis of exosomes derived from TAMs, we identified miRNAs enriched in the exosomes, including miR-29a-3p and miR-21-5p. When the two miRNA mimics were transfected into CD4
T cells, they directly suppressed STAT3 and regulated Treg/Th17 cells, inducing an imbalance, and they had a synergistic effect on STAT3 inhibition. Taken together, these results indicate that exosomes mediate the interaction between TAMs and T cells, generating an immune-suppressive microenvironment that facilitates EOC progression and metastasis. These findings suggest that targeting these exosomes or their associated miRNAs might pave the way for the development of novel treatments for EOC. |
|---|---|
| AbstractList | The immune microenvironment is crucial for epithelial ovarian cancer (EOC) progression and consists of tumor-associated macrophages (TAM) and T lymphocytes, such as regulatory T cells (Treg) and T helper 17 (Th17) cells. In this study, the Treg/Th17 ratio was significantly higher in EOC
and in metastatic peritoneal tissues than in benign ovarian tumors and benign peritoneum. The Treg/Th17 ratio was associated with histologic grade and was an independent prognostic factor for overall survival of EOC patients. On the basis of microarray analysis of exosomes derived from TAMs, we identified miRNAs enriched in the exosomes, including miR-29a-3p and miR-21-5p. When the two miRNA mimics were transfected into CD4
T cells, they directly suppressed STAT3 and regulated Treg/Th17 cells, inducing an imbalance, and they had a synergistic effect on STAT3 inhibition. Taken together, these results indicate that exosomes mediate the interaction between TAMs and T cells, generating an immune-suppressive microenvironment that facilitates EOC progression and metastasis. These findings suggest that targeting these exosomes or their associated miRNAs might pave the way for the development of novel treatments for EOC. |
| Author | Li, Xiaoduan Zhou, Jieru Zhang, Ting Lin, Yingying Zhu, Qinyi Wang, Husheng Wu, Xiaoli Wang, Xipeng Wang, Kai Wang, Xinjing |
| Author_xml | – sequence: 1 givenname: Jieru surname: Zhou fullname: Zhou, Jieru organization: Department of Obstetrics and Gynaecology, XinHua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China – sequence: 2 givenname: Xiaoduan surname: Li fullname: Li, Xiaoduan organization: Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China – sequence: 3 givenname: Xiaoli surname: Wu fullname: Wu, Xiaoli organization: Department of Obstetrics and Gynaecology, XinHua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China – sequence: 4 givenname: Ting surname: Zhang fullname: Zhang, Ting organization: Center for Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Renji Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China – sequence: 5 givenname: Qinyi surname: Zhu fullname: Zhu, Qinyi organization: Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China – sequence: 6 givenname: Xinjing surname: Wang fullname: Wang, Xinjing organization: Department of Obstetrics and Gynaecology, XinHua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China – sequence: 7 givenname: Husheng surname: Wang fullname: Wang, Husheng organization: Department of Obstetrics and Gynaecology, XinHua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China – sequence: 8 givenname: Kai surname: Wang fullname: Wang, Kai organization: Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China – sequence: 9 givenname: Yingying surname: Lin fullname: Lin, Yingying email: wangxipeng@xinhuamed.com.cn, yylin@sibs.ac.cn organization: Department of Neurosurgery, RenJi Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. wangxipeng@xinhuamed.com.cn yylin@sibs.ac.cn – sequence: 10 givenname: Xipeng surname: Wang fullname: Wang, Xipeng email: wangxipeng@xinhuamed.com.cn, yylin@sibs.ac.cn organization: Department of Obstetrics and Gynaecology, XinHua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. wangxipeng@xinhuamed.com.cn yylin@sibs.ac.cn |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30396909$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1kM1OwzAQhC0EoqX0EUB-gbS249jxsYoKRAIqVeFcrZNNE5Q_2SmCJ-C1CaLsZbTzjeYwN-Sy6zsk5I6zFedRvBahUIFiSq2SdB9wHTCpzQWZn30tZ2Tp_TubLo4lj-Q1mYUsNMowMyff28_e9y16uscGwWNBS9e3NDu1vQs23vd5DePkvkDu-qGC4xTNHHS-REfbev-6mf4KRpp2xSlHChPF4zqruKYJNg1NWwsNdBOqO7od6rHCpoaG7j7A1dDR5Je5W3JVQuNxedYFeXvYZslT8Lx7TJPNc5CHzIwBWKmZYSo2zKLAkPNcKKkUK0u0eVjEOpJCi9IKVkTammIawyoZay0ZL6QWC3L_1zucbIvFYXB1C-7r8L-I-AFO2mRW |
| CitedBy_id | crossref_primary_10_1016_j_apsb_2023_03_025 crossref_primary_10_1016_j_intimp_2024_112406 crossref_primary_10_3389_fimmu_2023_1228331 crossref_primary_10_1007_s11064_021_03231_2 crossref_primary_10_1111_cas_14599 crossref_primary_10_1007_s11060_023_04257_y crossref_primary_10_1002_cac2_12546 crossref_primary_10_1007_s10565_021_09650_9 crossref_primary_10_1186_s13045_022_01305_4 crossref_primary_10_1155_2019_4197829 crossref_primary_10_3390_biology9110380 crossref_primary_10_1007_s43032_021_00717_w crossref_primary_10_3389_fimmu_2025_1525052 crossref_primary_10_1016_j_phymed_2021_153917 crossref_primary_10_1016_j_canlet_2022_215823 crossref_primary_10_3390_ijms23094493 crossref_primary_10_1007_s10565_023_09793_x crossref_primary_10_3390_cancers12082025 crossref_primary_10_1186_s12951_023_02105_9 crossref_primary_10_3389_fimmu_2023_1270411 crossref_primary_10_4196_kjpp_2023_27_2_157 crossref_primary_10_1080_2162402X_2021_1887552 crossref_primary_10_3389_fimmu_2023_1264774 crossref_primary_10_1016_j_colsurfa_2021_128184 crossref_primary_10_1016_j_yexcr_2020_112393 crossref_primary_10_1016_j_ajps_2023_100870 crossref_primary_10_1016_j_ijbiomac_2023_126300 crossref_primary_10_3390_biomedicines9091257 crossref_primary_10_1016_j_bbcan_2021_188624 crossref_primary_10_1016_j_canlet_2022_215979 crossref_primary_10_1016_j_yexcr_2023_113621 crossref_primary_10_4251_wjgo_v16_i3_630 crossref_primary_10_1038_s41392_025_02124_y crossref_primary_10_1186_s40364_022_00374_4 crossref_primary_10_1186_s12964_023_01408_6 crossref_primary_10_2147_OTT_S281909 crossref_primary_10_1016_j_ymthe_2021_08_003 crossref_primary_10_1021_acs_jafc_3c06104 crossref_primary_10_1016_j_canlet_2022_215975 crossref_primary_10_3389_fimmu_2021_590447 crossref_primary_10_1002_hed_26888 crossref_primary_10_3389_fendo_2022_886533 crossref_primary_10_1016_j_pharmthera_2020_107585 crossref_primary_10_1155_2021_3710372 crossref_primary_10_1007_s13205_022_03217_z crossref_primary_10_3389_fimmu_2022_784374 crossref_primary_10_1016_j_jhepr_2024_101242 crossref_primary_10_3389_fimmu_2023_1320305 crossref_primary_10_1186_s13045_024_01528_7 crossref_primary_10_3389_fcell_2022_913110 crossref_primary_10_1016_j_intimp_2023_110415 crossref_primary_10_3390_jcm8070959 crossref_primary_10_1208_s12248_021_00554_4 crossref_primary_10_1038_s41523_022_00476_0 crossref_primary_10_1080_13880209_2023_2244004 crossref_primary_10_3389_fbioe_2022_876151 crossref_primary_10_3390_cells11203305 crossref_primary_10_1155_2019_4649705 crossref_primary_10_3390_cells10102533 crossref_primary_10_3389_fimmu_2023_1113312 crossref_primary_10_1016_j_ymthe_2020_06_003 crossref_primary_10_1186_s13046_021_01957_z crossref_primary_10_1016_j_ejcb_2024_151447 crossref_primary_10_1002_smll_202105414 crossref_primary_10_3390_cancers14092220 crossref_primary_10_1111_1471_0528_17446 crossref_primary_10_3389_fphar_2022_895254 crossref_primary_10_1002_mco2_551 crossref_primary_10_3390_cells13161343 crossref_primary_10_3390_jcm9103226 crossref_primary_10_1007_s00281_023_00988_2 crossref_primary_10_3390_ijms22010014 crossref_primary_10_1167_iovs_64_4_28 crossref_primary_10_1186_s12943_024_02103_x crossref_primary_10_1002_path_5403 crossref_primary_10_1186_s12943_023_01741_x crossref_primary_10_31083_j_fbl2704139 crossref_primary_10_5306_wjco_v12_i10_845 crossref_primary_10_1002_cac2_12345 crossref_primary_10_1016_j_bbrep_2023_101542 crossref_primary_10_1016_j_celrep_2019_05_008 crossref_primary_10_3390_cancers13174380 crossref_primary_10_1128_MMBR_00064_19 crossref_primary_10_1186_s13046_022_02458_3 crossref_primary_10_1016_j_ymthe_2022_01_046 crossref_primary_10_1016_j_omtn_2021_05_011 crossref_primary_10_3390_ncrna7010004 crossref_primary_10_1016_j_phrs_2023_106756 crossref_primary_10_1097_QAI_0000000000002565 crossref_primary_10_1080_14737140_2020_1760095 crossref_primary_10_1038_s12276_021_00699_4 crossref_primary_10_3389_fdgth_2020_573010 crossref_primary_10_3389_fonc_2022_1004700 crossref_primary_10_3390_ijms23136994 crossref_primary_10_1016_j_mtbio_2022_100218 crossref_primary_10_3389_fimmu_2020_01525 crossref_primary_10_1038_s41392_021_00499_2 crossref_primary_10_1177_15330338221114497 crossref_primary_10_1186_s13071_019_3866_0 crossref_primary_10_3390_biomedicines11092534 crossref_primary_10_1038_s41419_024_07004_x crossref_primary_10_1136_jitc_2021_002873 crossref_primary_10_1136_jitc_2022_005968 crossref_primary_10_1186_s12967_020_02652_x crossref_primary_10_1016_j_actbio_2023_05_007 crossref_primary_10_1016_j_bcp_2024_116699 crossref_primary_10_1111_jcmm_16374 crossref_primary_10_3389_fphar_2024_1452276 crossref_primary_10_1111_sji_12807 crossref_primary_10_1016_j_ymthe_2021_12_002 crossref_primary_10_1002_EXP_20210144 crossref_primary_10_1016_j_ygyno_2024_09_019 crossref_primary_10_3389_fimmu_2022_913951 crossref_primary_10_1021_acsnano_4c09190 crossref_primary_10_3389_fonc_2024_1325575 crossref_primary_10_1016_j_apsb_2025_03_007 crossref_primary_10_1016_j_jconrel_2023_11_003 crossref_primary_10_1007_s00109_022_02276_2 crossref_primary_10_1038_s41423_024_01216_z crossref_primary_10_1016_j_isci_2023_106333 crossref_primary_10_1186_s12943_020_01199_1 crossref_primary_10_3390_ijms23010008 crossref_primary_10_3390_ijms22073374 crossref_primary_10_1016_j_apsb_2020_04_004 crossref_primary_10_1016_j_trecan_2020_02_013 crossref_primary_10_1158_1535_7163_MCT_22_0351 crossref_primary_10_1007_s12094_023_03240_3 crossref_primary_10_1016_j_canlet_2021_12_007 crossref_primary_10_2217_epi_2019_0165 crossref_primary_10_3389_fimmu_2021_593473 crossref_primary_10_1136_jitc_2021_004113 crossref_primary_10_1002_cam4_3505 crossref_primary_10_1016_j_prp_2024_155261 crossref_primary_10_32604_or_2023_030401 crossref_primary_10_1007_s00018_022_04164_x crossref_primary_10_1080_08923973_2024_2412110 crossref_primary_10_3390_ijms24119279 crossref_primary_10_3390_ijms21072286 crossref_primary_10_3390_ijms21197093 crossref_primary_10_1016_j_lfs_2020_118687 crossref_primary_10_1097_CM9_0000000000003078 crossref_primary_10_1007_s43032_021_00789_8 crossref_primary_10_3390_cancers15061650 crossref_primary_10_1007_s00262_024_03674_w crossref_primary_10_3390_cells9092061 crossref_primary_10_1016_j_semcdb_2023_01_008 crossref_primary_10_1021_acsbiomaterials_2c00893 crossref_primary_10_1111_cei_13639 crossref_primary_10_1186_s13045_020_00987_y crossref_primary_10_1186_s13045_021_01198_9 crossref_primary_10_3892_ijo_2022_5347 crossref_primary_10_3389_fonc_2023_1166860 crossref_primary_10_1126_sciadv_abb0737 crossref_primary_10_3389_fgene_2022_848985 crossref_primary_10_1002_ctm2_288 crossref_primary_10_1002_pro6_66 crossref_primary_10_1007_s10565_022_09744_y crossref_primary_10_3390_ijms20102401 crossref_primary_10_3390_cancers14143404 crossref_primary_10_3892_ijo_2022_5450 crossref_primary_10_1002_pmic_202200204 crossref_primary_10_1186_s12935_022_02594_y crossref_primary_10_1002_jcp_28905 crossref_primary_10_1016_j_bbadis_2023_166917 crossref_primary_10_1016_j_nantod_2023_102129 crossref_primary_10_3390_biom14091099 crossref_primary_10_1016_j_jare_2024_01_013 crossref_primary_10_1186_s12885_021_08729_0 crossref_primary_10_1080_21691401_2019_1596926 crossref_primary_10_1016_j_imlet_2020_08_003 crossref_primary_10_3389_fimmu_2022_923194 crossref_primary_10_3389_fimmu_2023_1161375 crossref_primary_10_3389_fonc_2020_00472 crossref_primary_10_1111_febs_15558 crossref_primary_10_1007_s13105_024_01050_x crossref_primary_10_3389_fmicb_2023_1115556 crossref_primary_10_3389_fimmu_2021_641937 crossref_primary_10_3390_ijms21197117 crossref_primary_10_1016_j_bioactmat_2023_09_018 crossref_primary_10_1002_wnan_2012 crossref_primary_10_1016_j_semcancer_2021_01_007 crossref_primary_10_1146_annurev_cancerbio_042920_104912 crossref_primary_10_1038_s41392_021_00506_6 crossref_primary_10_3390_ijms21228762 crossref_primary_10_1007_s00262_022_03305_2 crossref_primary_10_1155_2022_9719671 crossref_primary_10_3390_ijms20236016 crossref_primary_10_1016_j_jpha_2023_11_008 crossref_primary_10_1136_jitc_2021_003217 crossref_primary_10_1002_cam4_3252 crossref_primary_10_1089_ars_2022_0035 crossref_primary_10_1158_1940_6207_CAPR_20_0053 crossref_primary_10_1016_j_semcdb_2021_04_001 crossref_primary_10_1002_ctm2_1425 crossref_primary_10_1016_j_semcancer_2021_08_001 crossref_primary_10_1186_s12943_025_02282_1 crossref_primary_10_1631_jzus_B1900452 crossref_primary_10_3390_cells10113155 crossref_primary_10_1007_s00262_020_02616_6 crossref_primary_10_3390_cells10010056 crossref_primary_10_1002_adbi_201900008 crossref_primary_10_1007_s00432_023_04833_9 crossref_primary_10_3389_fimmu_2022_1050917 crossref_primary_10_3390_cancers11091280 crossref_primary_10_1016_j_canlet_2024_216610 crossref_primary_10_1097_HC9_0000000000000616 crossref_primary_10_1186_s40364_023_00538_w crossref_primary_10_3390_cancers12010024 crossref_primary_10_1016_j_semcdb_2021_04_013 crossref_primary_10_3389_fimmu_2022_1018256 crossref_primary_10_1002_ijc_33408 crossref_primary_10_3389_fimmu_2021_669992 crossref_primary_10_1038_s41419_020_03127_z crossref_primary_10_1038_s41419_022_04534_0 crossref_primary_10_1002_jcp_28785 crossref_primary_10_1016_j_hbpd_2024_04_004 crossref_primary_10_1186_s12935_024_03525_9 crossref_primary_10_3390_ijms21051673 crossref_primary_10_1002_advs_201900582 crossref_primary_10_3389_fonc_2021_631703 crossref_primary_10_1016_j_jep_2022_116086 crossref_primary_10_1016_j_heliyon_2024_e30603 crossref_primary_10_1002_adbi_202000061 crossref_primary_10_1016_j_pharmthera_2021_107969 crossref_primary_10_1111_prd_12520 crossref_primary_10_3389_fimmu_2023_1287465 crossref_primary_10_3390_cancers12113455 crossref_primary_10_1002_advs_202309298 crossref_primary_10_3389_fphar_2023_1082066 crossref_primary_10_1038_s41419_021_03490_5 crossref_primary_10_1016_j_intimp_2024_113248 crossref_primary_10_1080_14737159_2020_1688144 crossref_primary_10_1016_j_intimp_2024_112150 crossref_primary_10_3390_biomedicines9101494 crossref_primary_10_14336_AD_2021_1023 crossref_primary_10_1007_s40618_020_01401_7 crossref_primary_10_1002_iid3_743 crossref_primary_10_1186_s40364_023_00537_x crossref_primary_10_1016_j_bbcan_2022_188784 crossref_primary_10_1021_acsnano_1c00672 crossref_primary_10_1038_s41392_021_00484_9 crossref_primary_10_3389_frph_2023_1130849 crossref_primary_10_3390_jnt3010005 crossref_primary_10_1002_adhm_202100650 crossref_primary_10_1016_j_addr_2021_113838 crossref_primary_10_1186_s13048_024_01417_0 crossref_primary_10_1186_s12943_020_01278_3 crossref_primary_10_1166_jbn_2021_3066 crossref_primary_10_3389_fimmu_2022_1071223 crossref_primary_10_3390_cancers12030561 crossref_primary_10_1210_endocr_bqae127 crossref_primary_10_1038_s41368_020_00100_6 crossref_primary_10_1016_j_semcancer_2024_08_006 crossref_primary_10_1016_j_ygyno_2021_02_004 crossref_primary_10_1186_s12943_024_01967_3 crossref_primary_10_1080_13543784_2024_2360209 crossref_primary_10_1016_j_cytogfr_2022_07_005 crossref_primary_10_1051_e3sconf_202129203089 crossref_primary_10_1038_s41419_024_06494_z crossref_primary_10_1038_s41419_022_04510_8 crossref_primary_10_1016_j_intimp_2022_109605 crossref_primary_10_3390_cancers12071761 |
| ContentType | Journal Article |
| Copyright | 2018 American Association for Cancer Research. |
| Copyright_xml | – notice: 2018 American Association for Cancer Research. |
| DBID | NPM |
| DOI | 10.1158/2326-6066.CIR-17-0479 |
| DatabaseName | PubMed |
| DatabaseTitle | PubMed |
| DatabaseTitleList | PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2326-6074 |
| ExternalDocumentID | 30396909 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | 53G ADCOW AENEX AFHIN AFUMD ALMA_UNASSIGNED_HOLDINGS EBS EJD H13 NPM OK1 RCR RHI |
| ID | FETCH-LOGICAL-c309t-ab470906890be2e311c264660ffebc3d8754272fb20d57b9d047b64877401d472 |
| IngestDate | Thu Apr 03 07:03:02 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Language | English |
| License | 2018 American Association for Cancer Research. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c309t-ab470906890be2e311c264660ffebc3d8754272fb20d57b9d047b64877401d472 |
| PMID | 30396909 |
| ParticipantIDs | pubmed_primary_30396909 |
| PublicationCentury | 2000 |
| PublicationDate | 2018-12-00 |
| PublicationDateYYYYMMDD | 2018-12-01 |
| PublicationDate_xml | – month: 12 year: 2018 text: 2018-12-00 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Cancer immunology research |
| PublicationTitleAlternate | Cancer Immunol Res |
| PublicationYear | 2018 |
| SSID | ssj0000884154 |
| Score | 2.594436 |
| Snippet | The immune microenvironment is crucial for epithelial ovarian cancer (EOC) progression and consists of tumor-associated macrophages (TAM) and T lymphocytes,... |
| SourceID | pubmed |
| SourceType | Index Database |
| StartPage | 1578 |
| Title | Exosomes Released from Tumor-Associated Macrophages Transfer miRNAs That Induce a Treg/Th17 Cell Imbalance in Epithelial Ovarian Cancer |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/30396909 |
| Volume | 6 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ1ba9swFIBF2kHpy-jud_Swt6DWF1m2H0vIaAftIKQs7KVYlrwYmjhkcSn7A_0v_ZU7R5fEpB10ezGJZITR-dA5OpwLIZ91IYRKVcxAO0nGFeesAE3IeJILXkgVl8YPeXYuTi7410ky6fXuOlFL7Uoelr8fzCv5H6nCGMgVs2T_QbLrRWEAfoN84QkShuejZDy8aX41WG1pBMoD1JGy2SLjdtYsmd94jYEU2KhrWmA9B6OcKr3sz-rR-TH8nxarPjbwwMwBmNU_sZ7INEz7A3Trnc4kBj-WprbIcIEZHFfoZP92DZdsOBsGOLfsmrh2pF9j4okt8OQKCq0dzz-mTWvoAZXcriOCTFjBpC4a1W6I_d760av6no977NWu81qEWScCRJvTDSw5wURgW_T4o1h0iYs652qY2EY_9w_8BJMY3GJCHA5ORwz0LhbO774PclvMDAWgsnORB4-Y3arD7ad2yA7cSLDFqvMLGZ2fZWAJcZciBh919OAn7ZM9v8zWNcaYM-MD8tTdQ-ixheoZ6en5c7J35iItXpBbzxb1bFFki26zRTtsUc8WtWxRZItatmhBka0jJIsiWXRNFq3ndEMWdWRRy9FLcvFlOB6cMNe0g5VxkK9YIXka5IHI8kDqSMdhWILNLURQVVqWscqw5XIaVTIKVJLKXMG-SAHXZmwNqXgavSK782au3xCqq0xHVax0kkQc3sxSGedJWYEJH1Vc6bfktd3Cy4WtzHLpN_fdX2fek_0Njh_IkwqOAv0R7MqV_GRE-gfXCXYF |
| linkProvider | National Library of Medicine |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Exosomes+Released+from+Tumor-Associated+Macrophages+Transfer+miRNAs+That+Induce+a+Treg%2FTh17+Cell+Imbalance+in+Epithelial+Ovarian+Cancer&rft.jtitle=Cancer+immunology+research&rft.au=Zhou%2C+Jieru&rft.au=Li%2C+Xiaoduan&rft.au=Wu%2C+Xiaoli&rft.au=Zhang%2C+Ting&rft.date=2018-12-01&rft.eissn=2326-6074&rft.volume=6&rft.issue=12&rft.spage=1578&rft_id=info:doi/10.1158%2F2326-6066.CIR-17-0479&rft_id=info%3Apmid%2F30396909&rft_id=info%3Apmid%2F30396909&rft.externalDocID=30396909 |