Corneal curvature-associated MTOR variant differentiates mild myopia from high myopia in Han Chinese population

• Published in: Ophthalmic genetics Vol. 42; no. 4; pp. 446 - 457
• Main Authors: Yuan, Xiang-Ling, Zhang, Riping, Zheng, Yuqian, Sun, Lixia, Wang, Geng, Chen, Shaowan, Xu, Yanxuan, Chen, Shao-Lang, Qiu, Kunliang, Ng, Tsz Kin
• Format: Journal Article
• Language: English
• Published: England 01.08.2021
• Subjects: Adult; Aged; Alleles; Asians - genetics; Axial Length, Eye; Biometry; China - epidemiology; Cornea - pathology; Eye Proteins - genetics; Female; Genetic Association Studies; Genetic Markers; Genome-Wide Association Study; Genotyping Techniques; Humans; Male; Middle Aged; Myopia - diagnosis; Myopia - genetics; Myopia, Degenerative - diagnosis; Myopia, Degenerative - genetics; Nucleoside-Phosphate Kinase - genetics; Polymorphism, Single Nucleotide; Receptor, Platelet-Derived Growth Factor alpha - genetics; Refraction, Ocular; Retinol-Binding Proteins - genetics; TOR Serine-Threonine Kinases - genetics; Wnt Proteins - genetics; Young Adult; China; genetic differentiation; corneal curvature; MTOR; Myopia

Myopia is the most prevalent ocular disorder in the world, and corneal parameters have been regarded as key ocular biometric parameters determining the refractive status. Here, we aimed to determine the association of genome-wide association study-identified corneal curvature (CC)-related gene varia...