Regional Differences in Protein Carboxymethylation in Post-Mortem Human Brain

• Published in: Clinical science (1979) Vol. 94; no. 6; pp. 677 - 685
• Main Authors: Goggins, Michael, Scott, John M., Weir, Donald G.
• Format: Journal Article
• Language: English
• Published: London Portland Press 01.06.1998
• Subjects: Adult; Aged; Aged, 80 and over; Analysis of Variance; Animals; Biological and medical sciences; Brain - enzymology; Brain - metabolism; Cerebellum - enzymology; Cerebellum - metabolism; Cerebral Cortex - enzymology; Cerebral Cortex - metabolism; Feasibility Studies; Female; Humans; Male; Medical sciences; Methylation; Middle Aged; Nervous system involvement in other diseases. Miscellaneous; Neurology; Protein O-Methyltransferase - analysis; Swine; Time Factors; Human; Evaluation; In vivo; Nervous system diseases; Autopsy; Response differentiation; Central nervous system disease; Carboxymethylation; Biological activity; Comparative study; Cerebral disorder

1. The aim of this study was to determine the pattern of protein carboxymethylation in different regions of the human brain. 2. The availability of protein methylation sites was determined by measurement of the incorporation of methyl-3H groups into proteins isolated from postmortem brain tissue. Th...