Improved production of poly-γ-glutamic acid with low molecular weight under high ferric ion concentration stress in Bacillus licheniformis ATCC 9945a

[Display omitted] •High Fe3+ concentrations lead to high γ-PGA production and low molecular weight.•High Fe3+ concentrations increase carbon source utilization for γ-PGA production.•The genes ggt and cwlO lead to low molecular weight under high Fe3+ concentrations. This study found that high ferric...

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Published inProcess biochemistry (1991) Vol. 56; pp. 30 - 36
Main Authors Feng, Jin, Shi, Qingshan, Zhou, Gang, Wang, Lingling, Chen, Aimei, Xie, Xiaobao, Huang, Xiaomo, Hu, Wenfeng
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.05.2017
Subjects
Ferric ions
Molecular weight
Poly-γ-glutamic acid
Transcription analysis
Yield
Yield
Ferric ions
Poly-γ-glutamic acid
Molecular weight
Transcription analysis
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Abstract [Display omitted] •High Fe3+ concentrations lead to high γ-PGA production and low molecular weight.•High Fe3+ concentrations increase carbon source utilization for γ-PGA production.•The genes ggt and cwlO lead to low molecular weight under high Fe3+ concentrations. This study found that high ferric ion (Fe3+) concentrations lead to high poly-γ-glutamic acid (γ-PGA) production and low-molecular-weight γ-PGA. In cultures containing 7.4mmol/L FeCl3, the average molecular weight of γ-PGA reached 3.18±0.3×105Da, which is a 76% decrease from that in the culture without FeCl3 (1.31±0.14×106Da). Cultures containing increasing concentrations of FeCl3 (0–7.4mmol/L) showed a corresponding increase in γ-PGA yield from 26.57±1.64 to 34.93±1.05g/L. Transcription level analysis indicated that high FeCl3 concentrations could enhance the expression of γ-PGA synthetase genes (pgsA, pgsB, and pgsC), which may contribute to the improved production of γ-PGA. In addition, γ-PGA degradation genes ggt (encoding γ-glutamyltransferase) and cwlO were found to contribute to a lower γ-PGA molecular weight in cultures containing 7.4mmol/L FeCl3. The result of γ-glutamyltransferase activity was in agreement with the results of the transcription level analysis. Overall, this study would provide a novel method for the regulation of synthesis of γ-PGA with low molecular weight.
AbstractList [Display omitted] •High Fe3+ concentrations lead to high γ-PGA production and low molecular weight.•High Fe3+ concentrations increase carbon source utilization for γ-PGA production.•The genes ggt and cwlO lead to low molecular weight under high Fe3+ concentrations. This study found that high ferric ion (Fe3+) concentrations lead to high poly-γ-glutamic acid (γ-PGA) production and low-molecular-weight γ-PGA. In cultures containing 7.4mmol/L FeCl3, the average molecular weight of γ-PGA reached 3.18±0.3×105Da, which is a 76% decrease from that in the culture without FeCl3 (1.31±0.14×106Da). Cultures containing increasing concentrations of FeCl3 (0–7.4mmol/L) showed a corresponding increase in γ-PGA yield from 26.57±1.64 to 34.93±1.05g/L. Transcription level analysis indicated that high FeCl3 concentrations could enhance the expression of γ-PGA synthetase genes (pgsA, pgsB, and pgsC), which may contribute to the improved production of γ-PGA. In addition, γ-PGA degradation genes ggt (encoding γ-glutamyltransferase) and cwlO were found to contribute to a lower γ-PGA molecular weight in cultures containing 7.4mmol/L FeCl3. The result of γ-glutamyltransferase activity was in agreement with the results of the transcription level analysis. Overall, this study would provide a novel method for the regulation of synthesis of γ-PGA with low molecular weight.
Author Chen, Aimei
Wang, Lingling
Xie, Xiaobao
Huang, Xiaomo
Hu, Wenfeng
Feng, Jin
Shi, Qingshan
Zhou, Gang
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  organization: College of Food Science, South China Agricultural University, Guangzhou, Guangdong 510062, People’s Republic of China
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Ferric ions
Poly-γ-glutamic acid
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Snippet [Display omitted] •High Fe3+ concentrations lead to high γ-PGA production and low molecular weight.•High Fe3+ concentrations increase carbon source utilization...
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SubjectTerms Ferric ions
Molecular weight
Poly-γ-glutamic acid
Transcription analysis
Yield
Title Improved production of poly-γ-glutamic acid with low molecular weight under high ferric ion concentration stress in Bacillus licheniformis ATCC 9945a
URI https://dx.doi.org/10.1016/j.procbio.2017.02.017
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