Indole-based heterocyclic inhibitors of p38α MAP kinase: designing a conformationally restricted analogue

• Published in: Bioorganic & medicinal chemistry letters Vol. 13; no. 18; pp. 3087 - 3090
• Main Authors: Mavunkel, Babu J, Chakravarty, Sarvajit, Perumattam, John J, Luedtke, Gregory R, Liang, Xi, Lim, Don, Xu, Yong-jin, Laney, Maureen, Liu, David Y, Schreiner, George F, Lewicki, John A, Dugar, Sundeep
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 2003

p38α Mitogen Activated Protein Kinase (MAP kinase) is an intracellular soluble serine threonine kinase. p38α kinase is activated in response to cellular stresses, growth factors and cytokines such as interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α). The central role of p38α activation in...