A portable device for real-time continuous drug monitoring in freely moving small animals

• Published in: Biosensors & bioelectronics Vol. 287; p. 117704
• Main Authors: Tsyban, Yurii, Shetty, Saptami Suresh, Li, Yanyan, de Oliveira Filho, José Ilton, Merzaban, Jasmeen S., Salama, Khaled Nabil
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.11.2025
• Subjects: Animals; Aptamers, Nucleotide - chemistry; Aptasensor; Biosensing Techniques - instrumentation; Closed-loop delivery; Drug Monitoring - instrumentation; Electrochemical sensor; Electrochemical Techniques - instrumentation; Equipment Design; In vivo biosensor; Portable potentiostat; Portable potentiostat; Closed-loop delivery; Electrochemical sensor; Aptasensor; In vivo biosensor

The large size and operational constraints of benchtop potentiostats, which typically require the use of anesthetized animals, have posed significant challenges for conducting real-time, long-term pharmacokinetic studies in freely moving subjects. This research addresses these challenges by developi...