Palladium-catalyzed direct arylation of indoles with arylsulfonyl hydrazides

A novel method to synthesise 2-arylindoles is demonstrated via direct arylation of indoles with arylsulfonyl hydrazides. Under the optimized reaction conditions, the reaction well tolerates a wide variety of functional groups to afford structurally diverse 2-arylindoles in good to excellent yields a...

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Published inOrganic & biomolecular chemistry Vol. 14; no. 1; pp. 2824 - 2827
Main Authors Liu, Congrong, Ding, Lianghui, Guo, Guang, Liu, Weiwei, Yang, Fu-Lai
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2016
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
DECARBONYLATIVE HECK OLEFINATION
ROOM-TEMPERATURE
CROSS-COUPLING REACTIONS
DIAZONIUM SALTS
BASE-FREE CONDITIONS
AROYL CHLORIDES
DIARYLIODONIUM SALTS
DIRECT C-2 ARYLATION
C-H ACTIVATION
DESULFITATIVE ARYLATION
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ISSN1477-0520
1477-0539
1477-0539
DOI10.1039/c5ob02569a

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Summary:A novel method to synthesise 2-arylindoles is demonstrated via direct arylation of indoles with arylsulfonyl hydrazides. Under the optimized reaction conditions, the reaction well tolerates a wide variety of functional groups to afford structurally diverse 2-arylindoles in good to excellent yields at 70 °C. A novel method to synthesise 2-arylindoles is demonstrated via direct arylation of indoles with arylsulfonyl hydrazides.
Bibliography:10.1039/c5ob02569a
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ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
1477-0539
DOI:10.1039/c5ob02569a