A Macrophage-Dominant PI3K Isoform Controls Hypoxia-Induced HIF1α and HIF2α Stability and Tumor Growth, Angiogenesis, and Metastasis - Joshi, Shweta; Singh, Alok R.; Zulcic, Muamera; Durden, Donald L. (Molecular cancer research, 2014)
Keywords: Animals; Basic Helix-Loop-Helix Transcription Factors - metabolism; Cell Hypoxia - drug effects; Cell Proliferation - drug effects; Chromones - pharmacology; Gene Deletion; Gene Expression Regulation, Neoplastic - drug effects; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Isoenzymes - metabolism; Macrophages - drug effects; Macrophages - enzymology; Mice; Models, Biological; Neoplasm Metastasis; Neoplasms - blood supply; Neoplasms - enzymology; Neoplasms - genetics; Neoplasms - pathology; Neovascularization, Pathologic - enzymology; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - pathology; Oligopeptides - pharmacology; Phosphatidylinositol 3-Kinases - metabolism; Proteasome Endopeptidase Complex - metabolism; Protein Kinase Inhibitors - pharmacology; Protein Stability - drug effects; Proteolysis - drug effects; Proto-Oncogene Proteins c-akt - metabolism; PTEN Phosphohydrolase - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Signal Transduction - drug effects; Transcription, Genetic - drug effects; Vascular Endothelial Growth Factor A - metabolism