Mitigation and mechanism of low dose linoleic acid on depression caused by disorder of gut microbiome

• Published in: Nutritional neuroscience Vol. 28; no. 2; pp. 245 - 262
• Main Authors: Yu, Haining, Song, Yinan, Lou, Maoshan, Shen, Shengrong
• Format: Journal Article
• Language: English
• Published: England 01.02.2025
• Subjects: Animals; Behavior, Animal - drug effects; Brain - drug effects; Brain - metabolism; Depression - drug therapy; Depression - etiology; Depression - microbiology; Gastrointestinal Microbiome - drug effects; Linoleic Acid - administration & dosage; Linoleic Acid - pharmacology; Male; Mice; Mice, Inbred C57BL; gut microbiome; ceftriaxone sodium; inflammation; lipid metabolism; linoleic acid; Depression; arachidonic acid metabolism; serotonin system

Depression is a widely prevalent mental disorder, and nutritional interventions play an increasingly important role in its treatment. In this paper, effects of linoleic acid (LA) on depressive behavior in mice induced by gut microbiome disorders were investigated. Fifty C57BL/6J male mice were rando...