Solvent-Free Method for Masking the Bitter Taste of Azithromycin Dihydrate Using Supercritical Fluid Technology

• Published in: Drug development and industrial pharmacy p. 1
• Main Authors: Mashaqbeh, Hadeia, Obaidat, Rana M, Alsmadi, Mo'tasem M
• Format: Journal Article
• Language: English
• Published: England 01.02.2024
• Subjects: Eudragit EPO; Polymeric Foaming; Supercritical fluid technology; Solvent Free process; Taste masking

The unpleasant extremely bitter taste of the orally administered broad-spectrum antibiotic azithromycin decreases patient compliance, especially in pediatrics. This issue can be overcome by decreasing drug interaction with the tasting buds using insoluble polymers at salivary pH (6.8 -7.4), like the...