Resistance to Pyrrolobenzodiazepine Dimers Is Associated with SLFN11 Downregulation and Can Be Reversed through Inhibition of ATR

• Published in: Molecular cancer therapeutics Vol. 20; no. 3; pp. 541 - 552
• Main Authors: Mao, Shenlan, Chaerkady, Raghothama, Yu, Wen, D’Angelo, Gina, Garcia, Andrew, Chen, Hong, Barrett, Allison M., Phipps, Sandrina, Fleming, Ryan, Hess, Sonja, Koopmann, Jens-Oliver, Dimasi, Nazzareno, Wilson, Susan, Pugh, Kathryn, Cook, Kimberly, Masterson, Luke A., Gao, Changshou, Wu, Herren, Herbst, Ronald, Howard, Philip W., Tice, David A., Cobbold, Mark, Harper, Jay
• Format: Journal Article
• Language: English
• Published: United States 01.03.2021

Resistance to antibody–drug conjugates (ADCs) has been observed in both preclinical models and clinical studies. However, mechanisms of resistance to pyrrolobenzodiazepine (PBD)-conjugated ADCs have not been well characterized and thus, this study was designed to investigate development of resistanc...