Soluble urine activated leukocyte cell adhesion molecule is a strong predictor of lupus nephritis

• Published in: Rheumatology (Oxford, England) Vol. 64; no. 5; pp. 2676 - 2687
• Main Authors: Chu, Dalena, Schwartz, Noa, Ampudia, Jeanette, Guthridge, Joel, James, Judith, Buyon, Jill P, Connelly, Stephen, Fung, Maple, Ng, Cherie T, Anolik, Jennifer, Apruzzese, William, Arazi, Arnon, Berthier, Celine, Brenner, Michael, Buyon, Jill, Clancy, Robert, Connery, Sean, Cunningham, Melissa, Dall’Era, Maria, Davidson, Anne, Der, Evan, Fava, Andrea, Fonseka, Chamith, Furie, Richard, Goldman, Dan, Gupta, Rohit, Hacohen, Nir, Hildeman, David, Hoover, Paul, Hsu, Raymond, Kado, Ruba, Kalunian, Ken, Kamen, Diane, Kretzler, Mattias, Maecker, Holden, Massarotti, Elena, McCune, William, McMahon, Maureen, Park, Meyeon, Payan-Schober, Fernanda, Pendergraft, William, Petri, Michelle, Pichavant, Mina, Putterman, Chaim, Rao, Deepak, Raychaudhuri, Soumya, Slowikowski, Kamil, Suryawanshi, Hemant, Tuschl, Thomas, Utz, P J, Waguespack, Dia, Wofsy, David, Zhang, Fan, Mohan, Chandra
• Format: Journal Article
• Language: English
• Published: England 01.05.2025
• Subjects: Activated-Leukocyte Cell Adhesion Molecule - blood; Activated-Leukocyte Cell Adhesion Molecule - urine; Adult; Antigens, CD - blood; Antigens, CD - urine; Antigens, Differentiation, T-Lymphocyte - urine; Biomarkers - blood; Biomarkers - urine; Cell Adhesion Molecules, Neuronal - blood; Cell Adhesion Molecules, Neuronal - urine; Cross-Sectional Studies; Disease Progression; Female; Humans; Longitudinal Studies; Lupus Nephritis - blood; Lupus Nephritis - diagnosis; Lupus Nephritis - urine; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; lupus nephritis; ALCAM; CD6; urine biomarkers

To evaluate urinary activated leucocyte cell adhesion molecule (ALCAM) and CD6 as predictors of LN progression or disease resolution across a 1-year study. Serum and urine samples from biopsy proven LN subjects (n = 122) were prospectively collected over the course of a year at 3- or 6-month interva...