Soluble urine activated leukocyte cell adhesion molecule is a strong predictor of lupus nephritis

To evaluate urinary activated leucocyte cell adhesion molecule (ALCAM) and CD6 as predictors of LN progression or disease resolution across a 1-year study. Serum and urine samples from biopsy proven LN subjects (n = 122) were prospectively collected over the course of a year at 3- or 6-month interva...

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Published inRheumatology (Oxford, England) Vol. 64; no. 5; pp. 2676 - 2687
Main Authors Chu, Dalena, Schwartz, Noa, Ampudia, Jeanette, Guthridge, Joel, James, Judith, Buyon, Jill P, Connelly, Stephen, Fung, Maple, Ng, Cherie T, Anolik, Jennifer, Apruzzese, William, Arazi, Arnon, Berthier, Celine, Brenner, Michael, Buyon, Jill, Clancy, Robert, Connery, Sean, Cunningham, Melissa, Dall’Era, Maria, Davidson, Anne, Der, Evan, Fava, Andrea, Fonseka, Chamith, Furie, Richard, Goldman, Dan, Gupta, Rohit, Hacohen, Nir, Hildeman, David, Hoover, Paul, Hsu, Raymond, Kado, Ruba, Kalunian, Ken, Kamen, Diane, Kretzler, Mattias, Maecker, Holden, Massarotti, Elena, McCune, William, McMahon, Maureen, Park, Meyeon, Payan-Schober, Fernanda, Pendergraft, William, Petri, Michelle, Pichavant, Mina, Putterman, Chaim, Rao, Deepak, Raychaudhuri, Soumya, Slowikowski, Kamil, Suryawanshi, Hemant, Tuschl, Thomas, Utz, P J, Waguespack, Dia, Wofsy, David, Zhang, Fan, Mohan, Chandra
Format Journal Article
LanguageEnglish
Published England 01.05.2025
Subjects
Activated-Leukocyte Cell Adhesion Molecule - blood
Activated-Leukocyte Cell Adhesion Molecule - urine
Adult
Antigens, CD - blood
Antigens, CD - urine
Antigens, Differentiation, T-Lymphocyte - urine
Biomarkers - blood
Biomarkers - urine
Cell Adhesion Molecules, Neuronal - blood
Cell Adhesion Molecules, Neuronal - urine
Cross-Sectional Studies
Disease Progression
Female
Humans
Longitudinal Studies
Lupus Nephritis - blood
Lupus Nephritis - diagnosis
Lupus Nephritis - urine
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
lupus nephritis
ALCAM
CD6
urine biomarkers
Online AccessGet full text
ISSN1462-0324
1462-0332
1462-0332
DOI10.1093/rheumatology/keae559

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Abstract To evaluate urinary activated leucocyte cell adhesion molecule (ALCAM) and CD6 as predictors of LN progression or disease resolution across a 1-year study. Serum and urine samples from biopsy proven LN subjects (n = 122) were prospectively collected over the course of a year at 3- or 6-month intervals (weeks 0, 12, 26 and 52) across multiple study sites and assessed for soluble ALCAM and CD6 levels. Urine creatinine from the same urine sample was used to normalize the levels of urinary ALCAM and urinary CD6. Measured levels of serum and urine ALCAM and CD6 were then analysed against disease metrics cross-sectionally and longitudinally. Cross-sectional analysis at baseline revealed that urinary ALCAM significantly correlated with urine protein creatinine ratio, renal SLEDAI, and the Physician Global Assessment (PGA), and negatively correlated with serum C3 and C4. Receiver operating characteristic curve analysis demonstrated that urinary ALCAM is a predictor of LN with an area under the curve (AUC) of 0.97, compared with urinary CD6 with an AUC of 0.71. Importantly, the change in urinary ALCAM over a 3-month period distinguished between non-responders and responders at week 52. Urinary ALCAM is reflective of changes in LN and may be predictive of response status.
AbstractList To evaluate urinary activated leucocyte cell adhesion molecule (ALCAM) and CD6 as predictors of LN progression or disease resolution across a 1-year study. Serum and urine samples from biopsy proven LN subjects (n = 122) were prospectively collected over the course of a year at 3- or 6-month intervals (weeks 0, 12, 26 and 52) across multiple study sites and assessed for soluble ALCAM and CD6 levels. Urine creatinine from the same urine sample was used to normalize the levels of urinary ALCAM and urinary CD6. Measured levels of serum and urine ALCAM and CD6 were then analysed against disease metrics cross-sectionally and longitudinally. Cross-sectional analysis at baseline revealed that urinary ALCAM significantly correlated with urine protein creatinine ratio, renal SLEDAI, and the Physician Global Assessment (PGA), and negatively correlated with serum C3 and C4. Receiver operating characteristic curve analysis demonstrated that urinary ALCAM is a predictor of LN with an area under the curve (AUC) of 0.97, compared with urinary CD6 with an AUC of 0.71. Importantly, the change in urinary ALCAM over a 3-month period distinguished between non-responders and responders at week 52. Urinary ALCAM is reflective of changes in LN and may be predictive of response status.
To evaluate urinary activated leucocyte cell adhesion molecule (ALCAM) and CD6 as predictors of lupus nephritis (LN) progression or disease resolution across a 1-year study.OBJECTIVESTo evaluate urinary activated leucocyte cell adhesion molecule (ALCAM) and CD6 as predictors of lupus nephritis (LN) progression or disease resolution across a 1-year study.Serum and urine samples from biopsy proven LN subjects (n = 122) were prospectively collected over the course of a year at 3- or 6-month intervals (weeks 0, 12, 26, and 52) across multiple study sites and assessed for soluble ALCAM and CD6 levels. Urine creatinine from the same urine sample was used to normalize the levels of urinary ALCAM and urinary CD6. Measured levels of serum and urine ALCAM and CD6 were then analyzed against disease metrics cross-sectionally and longitudinally.METHODSSerum and urine samples from biopsy proven LN subjects (n = 122) were prospectively collected over the course of a year at 3- or 6-month intervals (weeks 0, 12, 26, and 52) across multiple study sites and assessed for soluble ALCAM and CD6 levels. Urine creatinine from the same urine sample was used to normalize the levels of urinary ALCAM and urinary CD6. Measured levels of serum and urine ALCAM and CD6 were then analyzed against disease metrics cross-sectionally and longitudinally.Cross-sectional analysis at baseline revealed that urinary ALCAM significantly correlated with urine protein creatinine ratio (UPCR), renal SLEDAI, and the Physician Global Assessment (PGA), and negatively correlated with serum C3 and C4. Receiver operating characteristic (ROC) curve analysis demonstrated that urinary ALCAM is a predictor of LN with an area under the curve (AUC) of 0.97, compared with urinary CD6 with an AUC of 0.71. Importantly, the change in urinary ALCAM over a 3-month period distinguished between non-responders and responders at week 52.RESULTSCross-sectional analysis at baseline revealed that urinary ALCAM significantly correlated with urine protein creatinine ratio (UPCR), renal SLEDAI, and the Physician Global Assessment (PGA), and negatively correlated with serum C3 and C4. Receiver operating characteristic (ROC) curve analysis demonstrated that urinary ALCAM is a predictor of LN with an area under the curve (AUC) of 0.97, compared with urinary CD6 with an AUC of 0.71. Importantly, the change in urinary ALCAM over a 3-month period distinguished between non-responders and responders at week 52.Urinary ALCAM is reflective of changes in LN and may be predictive of response status.CONCLUSIONUrinary ALCAM is reflective of changes in LN and may be predictive of response status.
Author Park, Meyeon
Payan-Schober, Fernanda
Suryawanshi, Hemant
Chu, Dalena
Utz, P J
Connery, Sean
Connelly, Stephen
Goldman, Dan
James, Judith
Gupta, Rohit
Kalunian, Ken
Fava, Andrea
Pichavant, Mina
Raychaudhuri, Soumya
Schwartz, Noa
Arazi, Arnon
Kretzler, Mattias
Wofsy, David
Maecker, Holden
McMahon, Maureen
Anolik, Jennifer
Kamen, Diane
Mohan, Chandra
Brenner, Michael
Kado, Ruba
Rao, Deepak
Zhang, Fan
Fonseka, Chamith
Waguespack, Dia
Massarotti, Elena
Guthridge, Joel
Buyon, Jill P
Davidson, Anne
Hoover, Paul
Hsu, Raymond
Ampudia, Jeanette
Putterman, Chaim
Hildeman, David
Slowikowski, Kamil
Apruzzese, William
Ng, Cherie T
Tuschl, Thomas
Pendergraft, William
Clancy, Robert
Cunningham, Melissa
Der, Evan
Petri, Michelle
McCune, William
Furie, Richard
Hacohen, Nir
Fung, Maple
Dall’Era, Maria
Berthier, Celine
Buyon, Jill
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CitedBy_id crossref_primary_10_3390_mi16020156
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ContentType Journal Article
Contributor Park, Meyeon
Payan-Schober, Fernanda
Davidson, Anne
Suryawanshi, Hemant
Dall'Era, Maria
Hoover, Paul
Hsu, Raymond
Utz, P J
Connery, Sean
Putterman, Chaim
Goldman, Dan
Hildeman, David
James, Judith
Slowikowski, Kamil
Apruzzese, William
Gupta, Rohit
Kalunian, Ken
Tuschl, Thomas
Fava, Andrea
Pichavant, Mina
Raychaudhuri, Soumya
Pendergraft, William
Clancy, Robert
Cunningham, Melissa
Arazi, Arnon
Kretzler, Mattias
Wofsy, David
Maecker, Holden
Der, Evan
McMahon, Maureen
Petri, Michelle
McCune, William
Anolik, Jennifer
Furie, Richard
Hacohen, Nir
Kamen, Diane
Brenner, Michael
Kado, Ruba
Rao, Deepak
Zhang, Fan
Fonseka, Chamith
Berthier, Celine
Waguespack, Dia
Buyon, Jill
Massarotti, Elena
Guthridge, Joel
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CorporateAuthor The Accelerating Medicines Partnership: RA/SLE Network
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Thu Apr 24 23:12:20 EDT 2025
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Issue 5
Keywords lupus nephritis
ALCAM
CD6
urine biomarkers
Language English
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PublicationTitle Rheumatology (Oxford, England)
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Lei (2025050316135343900_keae559-B20) 2022; 13
Chalmers (2025050316135343900_keae559-B5) 2019
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Snippet To evaluate urinary activated leucocyte cell adhesion molecule (ALCAM) and CD6 as predictors of LN progression or disease resolution across a 1-year study....
To evaluate urinary activated leucocyte cell adhesion molecule (ALCAM) and CD6 as predictors of lupus nephritis (LN) progression or disease resolution across a...
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SubjectTerms Activated-Leukocyte Cell Adhesion Molecule - blood
Activated-Leukocyte Cell Adhesion Molecule - urine
Adult
Antigens, CD - blood
Antigens, CD - urine
Antigens, Differentiation, T-Lymphocyte - urine
Biomarkers - blood
Biomarkers - urine
Cell Adhesion Molecules, Neuronal - blood
Cell Adhesion Molecules, Neuronal - urine
Cross-Sectional Studies
Disease Progression
Female
Humans
Longitudinal Studies
Lupus Nephritis - blood
Lupus Nephritis - diagnosis
Lupus Nephritis - urine
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
Title Soluble urine activated leukocyte cell adhesion molecule is a strong predictor of lupus nephritis
URI https://www.ncbi.nlm.nih.gov/pubmed/39404817
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