RIPK3 Orchestrates Fatty Acid Metabolism in Tumor-Associated Macrophages and Hepatocarcinogenesis

• Published in: Cancer immunology research Vol. 8; no. 5; p. 710
• Main Authors: Wu, Lei, Zhang, Xiao, Zheng, Lu, Zhao, Huakan, Yan, Guifang, Zhang, Qi, Zhou, Yu, Lei, Juan, Zhang, Jiangang, Wang, Jingchun, Xin, Rong, Jiang, Lu, Peng, Jin, Chen, Qian, Lam, Sin Man, Shui, Guanghou, Miao, Hongming, Li, Yongsheng
• Format: Journal Article
• Language: English
• Published: United States 01.05.2020
• Subjects: Animals; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; Fatty Acids - metabolism; Humans; Liver Neoplasms - immunology; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Macrophages - immunology; Macrophages - metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; PPAR gamma - metabolism; Receptor-Interacting Protein Serine-Threonine Kinases - immunology; Receptor-Interacting Protein Serine-Threonine Kinases - metabolism; Tumor Microenvironment - immunology

Metabolic reprogramming is critical for the polarization and function of tumor-associated macrophages (TAM) and hepatocarcinogenesis, but how this reprogramming occurs is unknown. Here, we showed that receptor-interacting protein kinase 3 (RIPK3), a central factor in necroptosis, is downregulated in...