Examination of Subbasal Nerve Plexus and Central Corneal Stromal Microstructure in Subjects With Congenital Aniridia, Using in Vivo Confocal Laser Scanning Microscopy

• Published in: Current eye research Vol. 49; no. 6; pp. 582 - 590
• Main Authors: Csorba, Anita, Kormányos, Kitti, Csidey, Mária, Náray, Annamária, Kovács, Klaudia, Németh, Orsolya, Knézy, Krisztina, Bausz, Mária, Szigeti, Andrea, Szabó, Dorottya, Corton, Marta, Tory, Kálmán, Nagy, Zoltán Zsolt, Langenbucher, Achim, Maka, Erika, Szentmáry, Nóra
• Format: Journal Article
• Language: English
• Published: England 02.06.2024
• Subjects: Adolescent; Adult; Aniridia - diagnosis; Child; Corneal Stroma - innervation; Corneal Stroma - pathology; Female; Humans; Male; Microscopy, Confocal; Middle Aged; Nerve Fibers - pathology; Ophthalmic Nerve - pathology; Young Adult; Aniridia-associated keratopathy; in vivo confocal laser scanning microscopy; subbasal nerve plexus; corneal stroma; congenital aniridia

During life up to 70% of aniridia subjects develop aniridia-associated keratopathy (AAK). AAK is characterized by limbal stem cell insufficiency, impaired corneal epithelial cell differentiation and abnormal cell adhesion, which leads to centripetal spreading vascularization, conjunctivalization, an...