USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 83; no. 7; pp. 1074 - 1093
• Main Authors: Ren, Yidan, Feng, Maoxiao, Hao, Xiaodong, Liu, Xiaoyan, Li, Juan, Li, Peilong, Gao, Jie, Qi, Qiuchen, Du, Lutao, Wang, Chuanxin, Wang, Qin, Wang, Yunshan
• Format: Journal Article
• Language: English
• Published: United States 04.04.2023
• Subjects: Animals; Apoptosis; Caspases - metabolism; Gasdermins; Mice; Neoplasms - genetics; Pyroptosis - physiology; Tumor Microenvironment; Ubiquitin-Specific Proteases - metabolism

Pyroptosis is a type of programmed cell death characterized by the activation of inflammatory caspases and the cleavage of gasdermin proteins. Pyroptosis can suppress tumor development and induce antitumor immunity, and activating pyroptosis is a potential treatment strategy for cancer. To uncover a...