Will zilebesiran, an RNA interference therapy, be effective, safe, and improve the treatment of hypertension?

• Published in: Expert opinion on biological therapy Vol. 24; no. 12; p. 1329
• Main Author: Doggrell, Sheila A
• Format: Journal Article
• Language: English
• Published: England 01.12.2024
• Subjects: Animals; Antihypertensive Agents - adverse effects; Antihypertensive Agents - therapeutic use; Blood Pressure - drug effects; Humans; Hypertension - drug therapy; Hypertension - genetics; Renin-Angiotensin System - drug effects; Renin-Angiotensin System - genetics; RNA Interference; RNA interference therapy; Angiotensinogen inhibitor; clinical trials; zilebesiran; IONIS-AGT-LRx; hypertension; KARDIA-1

Less than half of the subjects with hypertension have been diagnosed and treated, with only 21% having their blood pressure under control. Many of the subjects find it difficult to adhere to daily antihypertensives. Zilebesiran reduces hepatic angiotensinogen messenger RNA levels to inhibit the reni...