Advances and critical concerns with the microfluidic enrichments of circulating tumor cells

• Published in: Lab on a chip Vol. 14; no. 1; pp. 45 - 56
• Main Authors: Hyun, Kyung-A, Jung, Hyo-Il
• Format: Journal Article
• Language: English
• Published: England 07.01.2014
• Subjects: Antibodies - chemistry; Antibodies - immunology; Antineoplastic Agents - therapeutic use; Biomarkers, Tumor - blood; Biomarkers, Tumor - metabolism; Cell Adhesion Molecules - immunology; Cell Adhesion Molecules - metabolism; Cell Separation - instrumentation; Cell Separation - methods; Humans; Immunomagnetic Separation - methods; Microfluidic Analytical Techniques - instrumentation; Microfluidic Analytical Techniques - methods; Neoplasms - diagnosis; Neoplasms - drug therapy; Neoplastic Cells, Circulating - metabolism

Over the past two decades, circulating tumor cells (CTCs) have been widely recognized for their importance in clinical trials. While most enrichment methods for these cells have been conducted through the batch process due to their rarity in blood and the need for large sample volumes, the batch pro...