Fatty acid binding to cyclooxygenases

• Published in: International Congress series Vol. 1233; pp. 283 - 289
• Main Authors: Malkowski, Michael G, Thuresson, Elizabeth D, Lakkides, Karen M, Rieke, Caroline Jill, Micielli, Renée, Garavito, R.Michael, Smith, William L
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.11.2002
• Subjects: Arachidonic acid; Aspirin; Cyclooxygenase; EPA; Polyunsaturated fatty acids; Cyclooxygenase; Aspirin; Arachidonic acid; Polyunsaturated fatty acids; EPA

Prostaglandin endoperoxide H synthase-1 and -2 (PGHS-1 and -2) convert arachidonic acid (AA) to prostaglandin H 2 (PGH 2) in the committed step in prostaglandin biosynthesis. Although the cyclooxygenase activity favors AA as the substrate, both isoforms will oxygenate a variety of 18–22 carbon fatty...