Focal and non-focal hepatic expression of placental glutathione S-transferase in carcinogen-treated rats

• Published in: Carcinogenesis (New York) Vol. 15; no. 11; p. 2587
• Main Authors: Dragan, Y P, Campbell, H A, Baker, K, Vaughan, J, Mass, M, Pitot, H C
• Format: Journal Article
• Language: English
• Published: England 01.11.1994
• Subjects: 9,10-Dimethyl-1,2-benzanthracene; Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Glutathione Transferase - analysis; Isoenzymes - analysis; Liver - enzymology; Liver Neoplasms, Experimental - enzymology; Placenta - enzymology; Precancerous Conditions - enzymology; Rats; Rats, Sprague-Dawley

Carcinogenesis develops in stages that have been operationally defined as initiation, promotion and progression. Although morphological end points have been described for detection and quantitation of these stages, to date initiation has been assessed only in the context of clonal growth in response...