Investigation Planning and Bioequivalence evaluation of Angiotensin II Receptor Antagonists

• Published in: Pharmaceutical chemistry journal Vol. 53; no. 8; pp. 680 - 684
• Main Authors: Romodanovskii, D. P., Goryachev, D. V., Khokhlov, A. L., Miroshnikov, A. N.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2019; Springer
• Subjects: Angiotensin; Evaluation; Investigations; Medicine; Organic Chemistry; Pharmacology/Toxicology; Pharmacy; Telmisartan; Valsartan; intra-individual variance; bioequivalence; angiotensin II receptor antagonists

Results of a retrospective analysis of bioequivalence studies of generic angiotensin II receptor antagonists are presented. Losartan, valsartan, and telmisartan medicines can be considered highly variable with respect to the pharmacokinetic parameter for maximum blood-plasma concentration. Candesart...