Lower diastolic velocity in the internal carotid artery mediates lower cerebral blood flow with age

• Published in: Journal of applied physiology (1985) Vol. 138; no. 6; pp. 1385 - 1397
• Main Authors: Ashley, John, Pasha, Evan P., Tarumi, Takashi, Tomoto, Tsubasa, Zhang, Rong
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.06.2025
• Subjects: Adult; Aged; Aged, 80 and over; Aging; Aging - physiology; Blood flow; Blood Flow Velocity - physiology; Carotid arteries; Carotid artery; Carotid Artery, Internal - physiology; Cerebral blood flow; Cerebrovascular Circulation - physiology; Diastole - physiology; Female; Humans; Infrared spectra; Infrared spectroscopy; Male; Middle Aged; Near infrared radiation; Oxygenation; Pulse Wave Analysis - methods; Stiffness; Ultrasonic imaging; Vascular Stiffness - physiology; Veins & arteries; Velocity; Vertebrae; Wave velocity; Young Adult; arterial stiffness; brain tissue; cerebral blood flow; aging; cerebral hemodynamics

In this study, we demonstrated that higher central arterial stiffness is associated with lower diastolic velocity of the ICA, which mediates lower CBF with age. These findings provide new mechanistic insights into the reduction in CBF with age and add to the mounting evidence for the importance of a...