Environmental Tobacco Smoke in Relation to Bladder Cancer Risk—The Shanghai Bladder Cancer Study

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 19; no. 12; pp. 3087 - 3095
• Main Authors: Tao, Li, Xiang, Yong-Bing, Wang, Renwei, Nelson, Heather H., Gao, Yu-Tang, Chan, Kenneth K., Yu, Mimi C., Yuan, Jian-Min
• Format: Journal Article
• Language: English
• Published: United States 01.12.2010
• Subjects: Arylamine N-Acetyltransferase - genetics; Arylamine N-Acetyltransferase - metabolism; China; Cytochrome P-450 CYP1A2 - genetics; Cytochrome P-450 CYP1A2 - metabolism; Environmental Exposure - adverse effects; Environmental Pollutants - adverse effects; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Phenotype; Risk Factors; Tobacco Smoke Pollution - adverse effects; Urinary Bladder Neoplasms - enzymology; Urinary Bladder Neoplasms - epidemiology; Urinary Bladder Neoplasms - genetics; China

Background: Environmental tobacco smoke (ETS) contains tobacco carcinogens. Hepatic cytochrome P450 (CYP) 1A2 and N-acetyltransferase (NAT2) are important isoenzymes in activation and detoxification, respectively, of tobacco carcinogens. Data on ETS and bladder cancer risk are sparse. Methods: We ex...