Acetaminophen‐induced acute liver failure Results of a United States multicenter, prospective study

• Published in: Hepatology (Baltimore, Md.) Vol. 42; no. 6; pp. 1364 - 1372
• Main Authors: Larson, Anne M., Polson, Julie, Fontana, Robert J., Davern, Timothy J., Lalani, Ezmina, Hynan, Linda S., Reisch, Joan S., Schiødt, Frank V., Ostapowicz, George, Shakil, A. Obaid, Lee, William M.
• Format: Journal Article
• Language: English
• Published: United States 01.12.2005
• Subjects: Acetaminophen - poisoning; Adolescent; Adult; Aged; Alcoholism - complications; APACHE; Drug Overdose; Female; Humans; Liver Failure, Acute - chemically induced; Liver Failure, Acute - epidemiology; Liver Failure, Acute - prevention & control; Male; Middle Aged; Prospective Studies

Severe acetaminophen hepatotoxicity frequently leads to acute liver failure (ALF). We determined the incidence, risk factors, and outcomes of acetaminophen-induced ALF at 22 tertiary care centers in the United States. Detailed prospective data were gathered on 662 consecutive patients over a 6-year...