Estimation of Glucose Absorption, Insulin Sensitivity, and Glucose Effectiveness From the Oral Glucose Tolerance Test

• Published in: The journal of clinical endocrinology and metabolism Vol. 110; no. 4; p. e1108
• Main Authors: Stefanovski, Darko, Smiley, Dawn D, Punjabi, Naresh M, Umpierrez, Guillermo E, Vellanki, Priyathama
• Format: Journal Article
• Language: English
• Published: United States 17.03.2025
• Subjects: Adult; Aged; Blood Glucose - analysis; Blood Glucose - metabolism; Cross-Sectional Studies; Diabetes Mellitus, Type 2 - metabolism; Female; Glucose - metabolism; Glucose Intolerance - diagnosis; Glucose Intolerance - metabolism; Glucose Tolerance Test; Humans; Insulin Resistance - physiology; Male; Middle Aged; Models, Biological; insulin sensitivity; minimal model; OGTT; glucose absorption; glucose effectiveness

Glucose tolerance during an oral glucose tolerance test (OGTT) is affected by variations in glucose effectiveness (GE) and glucose absorption and thus affects minimal model calculations of insulin sensitivity (SI). The widely used OGTT SI by Dalla Man et al does not account for variances in GE and g...