Effects of anti-tau immunotherapy on reactive microgliosis, cerebral endotheliopathy, and cognitive function in an experimental model of cerebral malaria

• Published in: Journal of neurochemistry Vol. 167; no. 3; pp. 441 - 460
• Main Authors: Akide Ndunge, Oscar B, Shikani, Henry J, Dai, Minxian, Freeman, Brandi D, Desruisseaux, Mahalia S
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.11.2023
• Subjects: Animals; Brain - pathology; Cell activation; Cell injury; Cognition; Cognitive ability; Complications; Congestion; Disease Models, Animal; Encephalopathy; Extracellular matrix; Glial cells; Humans; Immunotherapy; Impairment; Infections; Inflammation; Injury prevention; Malaria; Malaria, Cerebral - complications; Malaria, Cerebral - therapy; Mice; Mice, Inbred C57BL; Microvasculature; Monoclonal antibodies; Neurodegenerative diseases; Neurodegenerative Diseases - pathology; Neuroinflammatory Diseases; Neurological diseases; Pathogenesis; Phosphorylation; Plasmodium berghei; Proteins; Tau protein; tau Proteins; Vascular diseases; Vector-borne diseases; neural damage; Plasmodium berghei; cerebrovascular congestion; neuroinflammation; memory impairment; glial activation

Cerebral malaria (CM), a potentially fatal encephalopathy caused primarily by infection with Plasmodium falciparum, results in long-term adverse neuro-psychiatric sequelae. Neural cell injury contributes to the neurological deficits observed in CM. Abnormal regulation of tau, an axonal protein patho...