Differences in carcinogenesis by the length of carcinogen exposure period in rat colon

• Published in: Digestive diseases and sciences Vol. 46; no. 1; pp. 109 - 117
• Main Authors: ENDO, Tetsu, OOKAWA, Keizou, TANAKA, Masanori, NAKAJI, Shigeyuki, TSUCHIDA, Shigeki, SUGAWARA, Kazuo
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 2001; Springer Nature B.V
• Subjects: 1,2-Dimethylhydrazine - administration & dosage; Animals; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Carcinogens - administration & dosage; Carcinoma - chemically induced; Carcinoma - genetics; Carcinoma - pathology; Chemical agents; Colonic Neoplasms - chemically induced; Colonic Neoplasms - genetics; Colonic Neoplasms - pathology; Genes, APC - genetics; Genes, ras - genetics; Medical sciences; Methylnitronitrosoguanidine; Mutation; Rats; Rats, Inbred F344; Time Factors; Tumors; Rat; Rodentia; Malignant tumor; Carcinogenesis; Colonic disease; Carcinogen; Vertebrata; Experimental disease; Mammalia; Animal; Risk factor; Digestive diseases; Genetics; Intestinal disease; Colon; Mutation; Exposure time; Onc gene

To clarify the carcinogenic factors--whether it is the kind of carcinogen or their length of exposure--that determine whether colorectal cancer develops from an adenoma or develops de novo in the absence of an adenoma, we histopathologically analyzed a total of 229 rat colon tumors induced by admini...