Crocetin and crocin decreased cholesterol and triglyceride content of both breast cancer tumors and cell lines

• Published in: Avicenna journal of phytomedicine Vol. 10; no. 4; pp. 384 - 397
• Main Authors: Hashemi, Seyed Ali, Bathaie, Seyedeh Zahra, Mohagheghi, Mohammad Ali
• Format: Journal Article
• Language: English
• Published: Iran Mashhad University of Medical Sciences 01.07.2020
• Subjects: 4t1-induced breast tumor; docking; hmgcr; lipid content; mcf-7; mda-mb-231; Original; Docking; 4T1-induced breast tumor MDA-MB-231; Binding affinity; HMGCR; MCF-7; Lipid content

Inhibition of lipid metabolism in breast cancer has been suggested as an effective approach for cancer therapy. Saffron-derived crocetin (Crt) and crocin (Cro) with the known anticancer activity, have shown hypolipidemic effect in diabetes and atherosclerosis. Here, we investigated the effect of Crt...