Reconstitution of Norovirus-Specific T-Cell Responses Following Hematopoietic Stem Cell Transplantation in Patients With Inborn Errors of Immunity and Chronic Norovirus Infection

• Published in: The Journal of infectious diseases Vol. 231; no. 3; pp. 773 - 783
• Main Authors: Durkee-Shock, Jessica, Cohen, Ariella, Maghzian, Naseem, Pezzella, Gloria, Jensen-Wachspress, Mariah, Hostal, Anna, Barton, Karenna, Gangler, Krista, Dávila Saldaña, Blachy J, Chaimongkol, Natthawan, Bollard, Catherine M, Sosnovtsev, Stanislav V, Cohen, Jeffrey, Nagata, Bianca M, Alves, Derron A, Ghosh, Rajarshi, Seifert, Bryce A, Freeman, Alexandra, Gonzalez, Corina, Notarangelo, Luigi D, Green, Kim Y, Keller, Michael D
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 17.03.2025
• Subjects: Antibodies, Viral - blood; Caliciviridae Infections - blood; Caliciviridae Infections - immunology; Caliciviridae Infections - therapy; Caliciviridae Infections - virology; Hematopoietic Stem Cell Transplantation; Humans; Immune Reconstitution; Major; Norovirus - genetics; Norovirus - immunology; Norovirus - isolation & purification; T-Lymphocytes - immunology; Viral Load; X-Linked Combined Immunodeficiency Diseases - complications; X-Linked Combined Immunodeficiency Diseases - immunology; X-Linked Combined Immunodeficiency Diseases - therapy; T-cell immunity; hematopoietic stem cell transplantation; chronic norovirus; severe combined immunodeficiency; DOCK8 deficiency

Chronic norovirus infection (CNI) causes significant morbidity in immunocompromised patients. No effective prevention or treatment currently exists. Two patients with inborn errors of immunity, X-linked severe combined immunodeficiency (X-SCID) and DOCK8 deficiency, were followed longitudinally for...