The Mitonuclear Dimension of Neanderthal and Denisovan Ancestry in Modern Human Genomes

• Published in: Genome biology and evolution Vol. 9; no. 6; pp. 1567 - 1581
• Main Authors: Sharbrough, Joel, Havird, Justin C., Noe, Gregory R., Warren, Jessica M., Sloan, Daniel B.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.06.2017
• Subjects: Alleles; Animals; Cell Nucleus - chemistry; Cell Nucleus - genetics; DNA, Mitochondrial - chemistry; DNA, Mitochondrial - genetics; Evolution, Molecular; Gene Flow; Genome, Human; Hominidae - classification; Hominidae - genetics; Humans; Neanderthals - classification; Neanderthals - genetics; Nucleic Acid Conformation; Polymorphism, Genetic; Reproductive Isolation; cytonuclear interactions; OXPHOS enzymes; hybridization; human evolution; coevolution; speciation

Some human populations interbred with Neanderthals and Denisovans, resulting in substantial contributions to modern-human genomes. Therefore, it is now possible to use genomic data to investigate mechanisms that shaped historical gene flow between humans and our closest hominin relatives. More gener...