Sensitivity to Antimicrobial Drugs of Pseudomonas Aeruginosa Extreme-Resistant Strains Isolated in the Major Hospitals of Central Kazakhstan

• Published in: Open access Macedonian journal of medical sciences Vol. 5; no. 1; pp. 6 - 8
• Main Authors: Azizov, Ilya S., Lavrinenko, Alyona V., Belyaev, Ilya A., Babenko, Dmitry B., Shambilova, Natalya A., Bissenova, Nelya M.
• Format: Journal Article
• Language: English
• Published: Macedonia ID Design 2012/DOOEL Skopje 15.03.2017
• Subjects: Basic Science; Pseudomonas aeruginosa; VIM; MALDI-TOF; carbapenemases gene; Antibiotic resistance
• ISSN: 1857-9655; 1857-9655
• DOI: 10.3889/oamjms.2017.023

AIM: The article presents the current data on the sensitivity of the main 37 strains of eXtremaly Drugs Resistance (XDR) category to anti-pseudomonas drugs.MATERIAL AND METHODS: The strains were collected during the prospective multicenter study in large multidisciplinary hospitals of Central Kazakhstan. Susceptibility to antimicrobial drugs was carried out by disk method and the serial dilution method with the interpretation of the results according to EUCAST criteria. Detection of carbapenemases gene of VIM, IMP, NDM and GES classes was carried out by PCR method using the commercial kits.RESULTS: All identified carbapenemases were sorted to VIM class and accounted for 63.64%. Resistance to aminoglycoside drugs exceeded 80%. All the strains were susceptible to polymyxin.CONCLUSION: Thus, at the present stage the circulation of P. aeruginosa strains of XDR category continues in major hospitals in Kazakhstan. The strains remain sensitiveness only to polymyxin.