Single-Cell Chromatin Accessibility Analysis Reveals the Epigenetic Basis and Signature Transcription Factors for the Molecular Subtypes of Colorectal Cancers

• Published in: Cancer discovery Vol. 14; no. 6; pp. 1082 - 1105
• Main Authors: Liu, Zhenyu, Hu, Yuqiong, Xie, Haoling, Chen, Kexuan, Wen, Lu, Fu, Wei, Zhou, Xin, Tang, Fuchou
• Format: Journal Article
• Language: English
• Published: United States 03.06.2024
• Subjects: Chromatin - genetics; Chromatin - metabolism; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Single-Cell Analysis; Transcription Factors - genetics; Transcription Factors - metabolism

Colorectal cancer is a highly heterogeneous disease, with well-characterized subtypes based on genome, DNA methylome, and transcriptome signatures. To chart the epigenetic landscape of colorectal cancers, we generated a high-quality single-cell chromatin accessibility atlas of epithelial cells for 2...