Preparation and evaluation of new l-canavanine derivatives as nitric oxide synthase inhibitors

• Published in: Tetrahedron Vol. 57; no. 30; pp. 6557 - 6565
• Main Authors: Li, Xiaofeng, Atkinson, Robert N, Bruce King, S
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 23.07.2001; Elsevier
• Subjects: Chemistry; Chemistry, Organic; inhibitors; l-canavanine; nitric oxide synthases; Physical Sciences; Science & Technology; l-canavanine; nitric oxide synthases; inhibitors; RESTRICTED ARGININE ANALOGS; SELECTIVE-INHIBITION; DOMAIN; L-canavanine; METHYL-L-THIOCITRULLINE; POTENT; PTERIN; DIMER; SUBSTRATE; BINDING; PARADIGM

New derivatives of the amino acid l-canavanine were prepared by total chemical synthesis and evaluated as inhibitors of inducible nitric oxide synthase (NOS). Replacement of the δ-methylene group of known NOS inhibitors with an oxygen atom produced dramatic effects as to the ability of these compoun...