Exudates of Microcystis aeruginosa on oxidative stress and inflammatory responses in gills of Sinocyclocheilus grahami

• Published in: Ecotoxicology and environmental safety Vol. 280; p. 116587
• Main Authors: Li, Jun, Chang, Xuexiu, Zhao, Sen, Zhang, Yuanwei, Pu, Qi, Wang, Yuting, Li, Jiaojiao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.07.2024; Elsevier
• Subjects: Animals; Cyanobacterial blooms; Gills - drug effects; Gills - pathology; Immune response; Inflammation - chemically induced; Inflammation - pathology; Inflammatory factors; Lipid Metabolism - drug effects; Lipid peroxidation; Metabolism disorder; Microcystis; Oxidative Stress - drug effects; Phytosphingosine; FFA; MS-222; Inflammatory factors; DMSO; High-PHS; PRRs; Go; Q-PCR; Lipid peroxidation; LPO; MDA; TNF; MaE; DEGs; TBA; Phytosphingosine; OECD; ANOVA; NLR; V. natat; KEGG; NLRP3; PHS; NF- Kβ; TLR; MCs; GSH; IL; Immune response; Low-PHS; NKA; H&E; GST; SOD; Cyanobacterial blooms; GR; M. aeruginosa; MAPK; GPx; Metabolism disorder; TC; LC50; TG; S. grahami; CAT; ECHA; ROS; CHABs

Early cyanobacterial blooms studies observed that exposure to blue-green algae led to fish gills impairment. The objective of this work was to evaluate the toxic mechanisms of exudates of Microcystis aeruginosa (MaE) on fish gills. In this study, the toxic mechanism of MaE (2×106 cells/mL) and one o...