Characterization of the Safety and Pharmacokinetic Profile of D-Methadone, a Novel N-Methyl-D-Aspartate Receptor Antagonist in Healthy, Opioid-Naive Subjects: Results of Two Phase 1 Studies

• Published in: Journal of clinical psychopharmacology
• Main Authors: Bernstein, Galina, Davis, Kelly, Mills, Catherine, Wang, Lu, McDonnell, Michael, Oldenhof, John, Inturrisi, Charles, Manfredi, Paolo L, Vitolo, Ottavio V
• Format: Journal Article
• Language: English
• Published: United States 01.05.2019

N-methyl-D-aspartate (NMDA) receptor (NMDAR) antagonists are potential agents for the treatment of several central nervous system disorders including major depressive disorder. Racemic methadone, L-methadone, and D-methadone all bind the NMDAR with an affinity similar to that of established NMDAR an...