Luteolin prevents axitinib-induced kidney damage in mice

• Published in: Chemico-biological interactions Vol. 418; p. 111628
• Main Authors: Niu, Na, Li, Xu, Tang, Dong, Jin, Tian-Qing, Ji, Si-Wen, Yu, Chun-Lei, Li, Yong
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 05.09.2025
• Subjects: Animals; Axitinib; Axitinib - toxicity; Glomerulosclerosis; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Luteolin; Luteolin - pharmacology; Luteolin - therapeutic use; Male; Mice; Mice, Inbred C57BL; Nephrotoxicity; Podocytes - drug effects; Podocytes - metabolism; Podocytes - pathology; Proteinuria - chemically induced; Proteinuria - pathology; Proteinuria - prevention & control; TRPC6; Glomerulosclerosis; Axitinib; TRPC6; Luteolin; Nephrotoxicity

Axitinib, a tyrosine kinase inhibitor (TKI) with antiangiogenic effects, is used in anticancer therapy. Axitinib can cause dose-limiting adverse reactions such as proteinuria and renal function impairment, but the mechanisms remain unclear. This study aims to elucidate the mechanism of axitinib-indu...