Solution phase combinatorial chemistry. Discovery of 13- and 15-membered polyazapyridinocyclophane libraries with antibacterial activity

• Published in: Tetrahedron Vol. 54; no. 16; pp. 3999 - 4012
• Main Authors: An, Haoyun, Wang, Tingmin, Mohan, Venkatraman, Griffey, Richard H., Cook, P.Dan
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 16.04.1998; Elsevier
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; SMALL ORGANIC-MOLECULES; SMALL-MOLECULE LIBRARIES; GENERATION; TEMPLATE; STRATEGY; CHEMICAL LIBRARIES

A solution phase simultaneous addition of functionalities (SPSAF) combinatorial approach was utilized to synthesize 40 polyazacyclophane libraries (total complexity of 4275). Eighteen different functionality sets, utilizing 42 functionalities, were designed to disrupt RNA-protein interactions. Guani...