Melt granulation in a high shear mixer: optimization of mixture and process variables using a combined experimental design

• Published in: Chemometrics and intelligent laboratory systems Vol. 48; no. 1; pp. 59 - 70
• Main Authors: Campisi, B, Vojnovic, D, Chicco, D, Phan-Tan-Luu, R
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 14.06.1999
• Subjects: High shear mixer; Melt granulation; Mixture-process variable approach; Response surface methodology; Melt granulation; Mixture-process variable approach; High shear mixer; Response surface methodology

Melt granulation of a formulation of theophylline, containing lactose, microcrystalline cellulose and hydroxypropylmethylcellulose as excipients, was investigated in a 10 l high shear mixer as an alternative method to the wet granulation process, using polyethylene glycol 6000 as melting binder. The...