Melt granulation in a high shear mixer: optimization of mixture and process variables using a combined experimental design

Melt granulation of a formulation of theophylline, containing lactose, microcrystalline cellulose and hydroxypropylmethylcellulose as excipients, was investigated in a 10 l high shear mixer as an alternative method to the wet granulation process, using polyethylene glycol 6000 as melting binder. The...

Full description

Saved in:
Bibliographic Details
Published inChemometrics and intelligent laboratory systems Vol. 48; no. 1; pp. 59 - 70
Main Authors Campisi, B, Vojnovic, D, Chicco, D, Phan-Tan-Luu, R
Format Journal Article
LanguageEnglish
Published Elsevier B.V 14.06.1999
Subjects
Online AccessGet full text

Cover

Loading…