Prediction of the concentrations in rat tissues of the intravenous anaesthetic methohexital from a nonlinear pharmacokinetic model

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 3; no. 4; p. 323
• Main Authors: Wynn, R L, Gillis, P P, Lovelace, G, O'Reilly, J E
• Format: Journal Article
• Language: English
• Published: England 1985

A nonlinear pharmacokinetic model that describes the tissue distribution of intravenous anaesthetics was evaluated against experimental values for methohexital in the rat. There was excellent agreement between experimental and theoretical values for brain tissue, and good agreement for blood and adi...