Development and validation of a GC method for a key nemtabrutinib intermediate: Implementation of an in-situ free base sample preparation protocol

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 241; p. 116002
• Main Authors: Rivera, Nelo R., Zewge, Daniel, Arvary, Rebecca, Lin, Mingxiang, Lohani, Sachin
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 15.04.2024
• Subjects: Ambersep 900 hydroxide form resin; Cyrene amine; GC analysis; Nemtabrutinib intermediate; Toluenesulfonic acid salt; Ambersep 900 hydroxide form resin; Toluenesulfonic acid salt; Cyrene amine; GC analysis; Nemtabrutinib intermediate

A novel synthetic approach to nemtabrutinib (MK-1026) was recently developed in our laboratories. The chemistry goes through a cyrene amine intermediate which does not contain any chromophore. As a result, analysis of this key chiral intermediate by HPLC-UV is not feasible. Initial attempts to devel...