Activation of Collagen Gene Expression in Keloids: Co-Localization of Type I and VI Collagen and Transforming Growth Factor-β1 mRNA

• Published in: Journal of investigative dermatology Vol. 97; no. 2; pp. 240 - 248
• Main Authors: Peltonen, Juha, Hsiao, Li Li, Jaakkola, Sirkku, Sollberg, Stephan, Aumailley, Monique, Timpl, Rupert, Chu, Mon-Li, Uitto, Jouni
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.08.1991

Untreated, clinically active keloids were examined as a model system to study the spatial expression of extracellular matrix and transforming growth factor-β1 (TGF-β1) genes in fibrotic skin diseases. In situ hybridizations localized active expression of type I and VI collagen genes to the areas con...