Dopamine prevents impairment of autoregulation after traumatic brain injury in the newborn pig through inhibition of Up-regulation of endothelin-1 and extracellular signal-regulated kinase mitogen-activated protein kinase

• Published in: Pediatric critical care medicine Vol. 14; no. 2; p. e103
• Main Authors: Armstead, William M, Riley, John, Vavilala, Monica S
• Format: Journal Article
• Language: English
• Published: United States 01.02.2013
• Subjects: Analysis of Variance; Animals; Blood Pressure - drug effects; Brain Injuries - drug therapy; Brain Injuries - physiopathology; Cerebrovascular Circulation - drug effects; Cerebrovascular Circulation - physiology; Dopamine - pharmacology; Dopamine - therapeutic use; Endothelin-1 - metabolism; Extracellular Signal-Regulated MAP Kinases - metabolism; Female; Hypotension - prevention & control; Male; MAP Kinase Signaling System - drug effects; Sex Factors; Swine; Sympathomimetics - pharmacology; Sympathomimetics - therapeutic use; Up-Regulation - drug effects; Vasodilation - drug effects

Traumatic brain injury contributes to morbidity in children and boys are disproportionately represented. Autoregulation is impaired more in male compared with female piglets after traumatic brain injury through sex-dependent up-regulation of the spasmogen endothelin-1 and extracellular signal-regula...