Digoxin Is Associated With Increased All-cause Mortality in Patients With Atrial Fibrillation Regardless of Concomitant Heart Failure: A Meta-analysis

• Published in: Journal of cardiovascular pharmacology Vol. 66; no. 3; p. 270
• Main Authors: Wang, Zhi-Quan, Zhang, Rui, Chen, Man-Tian, Wang, Qun-Shan, Zhang, Yi, Huang, Xiao-Hong, Wang, Jun, Yan, Jian-Hua, Li, Yi-Gang
• Format: Journal Article
• Language: English
• Published: United States 01.09.2015
• Subjects: Anti-Arrhythmia Agents - administration & dosage; Anti-Arrhythmia Agents - adverse effects; Anti-Arrhythmia Agents - therapeutic use; Atrial Fibrillation - complications; Atrial Fibrillation - drug therapy; Atrial Fibrillation - mortality; Data Interpretation, Statistical; Databases, Factual; Digoxin - administration & dosage; Digoxin - adverse effects; Digoxin - therapeutic use; Heart Failure - complications; Heart Failure - drug therapy; Heart Failure - mortality; Humans; Mortality - trends

For decades, digoxin has been widely used to control ventricular rate in atrial fibrillation (AF). However, it remains controversial as to whether digoxin is associated with increased mortality in AF. In this study, we searched relevant studies that were published before December 1, 2014, in PubMed,...