Overexpression of Yes Associated Protein 1, an Independent Prognostic Marker in Patients With Pancreatic Ductal Adenocarcinoma, Correlated With Liver Metastasis and Poor Prognosis

• Published in: Pancreas Vol. 46; no. 7; p. 913
• Main Authors: Salcedo Allende, Maria Teresa, Zeron-Medina, Jorge, Hernandez, Javier, Macarulla, Teresa, Balsells, Joaquim, Merino, Xavier, Allende, Helena, Tabernero, Josep, Ramon Y Cajal, Santiago
• Format: Journal Article
• Language: English
• Published: United States 01.08.2017
• Subjects: Adaptor Proteins, Signal Transducing - biosynthesis; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - biosynthesis; Carcinoma, Pancreatic Ductal - metabolism; Carcinoma, Pancreatic Ductal - pathology; Female; Humans; Immunohistochemistry; Liver Neoplasms - metabolism; Liver Neoplasms - secondary; Male; Middle Aged; Multivariate Analysis; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Phosphoproteins - biosynthesis; Prognosis; Survival Analysis; Transcription Factors

Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer. Overexpression of Yes associated protein 1 (YAP1), a downstream target of Hippo pathway, implicated in regulation of cell growth and apoptosis, has been reported in several human tumor types. The objective of this study was to investigate Y...