The phosphorylation of Pak1 by Erk1/2 to drive cell migration requires Arl4D acting as a scaffolding protein

• Published in: Journal of cell science Vol. 138; no. 10
• Main Authors: Chang, Ting-Wei, Lin, Ming-Chieh, Yu, Chia-Jung, Lee, Fang-Jen S.
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists 15.05.2025
• Subjects: ADP-Ribosylation Factors - genetics; ADP-Ribosylation Factors - metabolism; Cell Membrane - metabolism; Cell Movement - physiology; HEK293 Cells; Humans; Mitogen-Activated Protein Kinase 1 - genetics; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - genetics; Mitogen-Activated Protein Kinase 3 - metabolism; p21-Activated Kinases - genetics; p21-Activated Kinases - metabolism; Phosphorylation; Erk1/2; Pak1 phosphorylation; PDGF; Cell migration; Arf-like 4 GTPase

Activation of extracellular signal-regulated kinases 1 and 2 (Erk1/2; also known as MAPK3 and MAPK1, respectively) at the plasma membrane usually leads to their translocation to various intracellular sites, where scaffolding proteins mediate substrate targeting. However, in platelet-derived growth f...