Berberine Directly Targets the NEK7 Protein to Block the NEK7–NLRP3 Interaction and Exert Anti-inflammatory Activity - Zeng, Qingxuan; Deng, Hongbin; Li, Yinghong; Fan, Tianyun; Liu, Yang; Tang, Sheng; Wei, Wei; Liu, Xiaojia; Guo, Xixi; Jiang, Jiandong; Wang, Yanxiang; Song, Danqing (Journal of medicinal chemistry, 2021)
Keywords: Animals; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - metabolism; Anti-Inflammatory Agents - pharmacology; Berberine - chemistry; Berberine - metabolism; Berberine - pharmacology; Binding Sites; Chemistry, Medicinal; Humans; Hydrogen Bonding; Interleukin-1beta - metabolism; Life Sciences & Biomedicine; Male; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Monocytes - cytology; Monocytes - drug effects; Monocytes - metabolism; NF-kappa B - metabolism; NIMA-Related Kinases - antagonists & inhibitors; NIMA-Related Kinases - genetics; NIMA-Related Kinases - metabolism; NLR Family, Pyrin Domain-Containing 3 Protein - chemistry; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Pharmacology & Pharmacy; Protein Interaction Domains and Motifs - drug effects; RNA Interference; RNA, Small Interfering - metabolism; Science & Technology; Signal Transduction - drug effects; Structure-Activity Relationship; MIGRATION; MECHANISM; SPECIFICITY; PRODUCTS; INSULIN-RESISTANCE; MACROPHAGES; NLRP3 INFLAMMASOME ACTIVATION; KINASE; ALPHA; UP-REGULATION