Mechanisms of adverse mammary effect induced by olanzapine and therapeutic interventions in rat model

• Published in: Toxicology and applied pharmacology Vol. 485; p. 116876
• Main Authors: Dong, Yingyue, Sun, Xiaozhe, Li, Hanxiao, Han, Chunmiao, Zhang, Yue, Ding, Huiru, Xia, Lisha, Wang, Huamin, Yang, Shaomin, Xu, Lingzi, Xu, Guoheng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2024
• Subjects: Antipsychotic; Aripiprazole; Hyperprolactinemia; Mammary gland; Olanzapine; Side effect; Antipsychotic; Olanzapine; Mammary gland; Aripiprazole; Hyperprolactinemia; Side effect

Olanzapine antagonizes dopamine receptors and is prescribed to treat multiple psychiatric conditions. The main side effect of concern for olanzapine is weight gain and metabolic syndrome. Olanzapine induces hyperprolactinemia, however its effect on the mammary gland is poorly documented. Rats receiv...