Roxadustat ameliorates experimental colitis in mice by regulating macrophage polarization through increasing HIF level

• Published in: Biochimica et biophysica acta. General subjects Vol. 1868; no. 3; p. 130548
• Main Authors: Kong, Guiping, Hua, Hu, Lu, Yan, Yan, Kunlong, Zheng, Yucan, Jia, Zhanjun, Guo, Hongmei, Li, Mei, Jin, Yu, Liu, Zhifeng
• Format: Journal Article
• Language: English
• Published: Netherlands 01.03.2024
• Subjects: Animals; Basic Helix-Loop-Helix Transcription Factors; Body Weight; Colitis - chemically induced; Colitis - drug therapy; Cytokines - metabolism; Hypoxia; Inflammatory Bowel Diseases; Macrophages - metabolism; Mice; Inflammatory-bowel disease; Macrophages polarization; HIF; Roxadustat

Gastro-intestinal (GI) tract inflammation is as a result of inflammatory hypoxia which is also induced by long-standing group of disorders like inflammatory-bowel disease (IBD). Regulation of GI immune homeostasis by macrophage involves hypoxia-inducible factor (HIF). As inhibitor of HIF prolyl hydr...