The role and mechanism of the NLRP3-IL-1β/IL-18 signaling axis in the progression of sepsis under an aging phenotype

• Published in: Life sciences (1973) Vol. 378; p. 123812
• Main Authors: Xu, Chuchu, Zhu, Renjun, Dai, Qingfeng, Xu, Guangen, Zhang, Guolin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.10.2025
• Subjects: Aging; Aging - metabolism; Animals; CLP model; Disease Models, Animal; Disease Progression; Female; Furans - pharmacology; Humans; IL-18; IL-1β; Indenes - pharmacology; Inflammasomes - metabolism; Interleukin-18 - metabolism; Interleukin-1beta - metabolism; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; NLRP3; Phenotype; Sepsis; Sepsis - metabolism; Sepsis - pathology; Signal Transduction; Sulfonamides; Aging; Sepsis; NLRP3; CLP model; IL-1β; IL-18

To investigate the impact of age on sepsis outcomes and explore potential therapeutic targets using the mouse model. Sepsis was induced via cecal ligation and puncture (CLP) in naturally aged mice (18 months) and young mice (3 months). Sepsis severity, mortality rates, bacterial loads, and cytokine...