The role and mechanism of the NLRP3-IL-1β/IL-18 signaling axis in the progression of sepsis under an aging phenotype - Xu, Chuchu; Zhu, Renjun; Dai, Qingfeng; Xu, Guangen; Zhang, Guolin (Life sciences (1973), 2025)
Keywords: Aging; Aging - metabolism; Animals; CLP model; Disease Models, Animal; Disease Progression; Female; Furans - pharmacology; Humans; IL-18; IL-1β; Indenes - pharmacology; Inflammasomes - metabolism; Interleukin-18 - metabolism; Interleukin-1beta - metabolism; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; NLRP3; Phenotype; Sepsis; Sepsis - metabolism; Sepsis - pathology; Signal Transduction; Sulfonamides; Aging; Sepsis; NLRP3; CLP model; IL-1β; IL-18